Understanding
Drug Discovery

Drug discovery is the process of identifying, screening, and developing new therapeutic candidates to treat disease. Spanning target validation, assay development, high-throughput screening, hit-to-lead efforts, and preclinical modelling, it requires precision, scalability, and reproducibility. The journey differs between small molecules, biologics, and cell- or gene-based therapies, yet the principles remain the same: to identify safe, effective, and scalable treatments.

Frequently Asked Questions (FAQ)

What is drug discovery?

Drug discovery is the process of identifying and developing new compounds or biologics with therapeutic potential. It includes target identification, screening, lead optimization, and preclinical evaluation.

It drives the development of therapies for diseases, improves patient outcomes, and addresses unmet medical needs. Efficient, reproducible workflows accelerate research and reduce development costs.

BICO accelerates drug discovery through workflow automation and predictive model creation. Green Button Go by Biosero gives researchers the ability to automate and orchestrate entire labs, coordinating machines across vendors, and increasing throughput. Our automated workstations coordinate and streamline complex experiments, such as Cell Line Development, reducing manual intervention.

Our 3D bioprinters by CELLINK enable the fabrication of physiologically relevant tissue models, offering an alternative to traditional 2D assays or animal studies and supporting more predictive preclinical evaluation.

The spheroONE by Cellenion enables the production of assay-ready plates for drug testing on homogenized 3D cell culture models (Spheroids and Organoids), further offering an alternative to traditional 2D assays and animal studies.

How we support drug discovery

We provide instruments and solutions spanning the entire drug discovery workflow. Our solutions boost efficiency and accuracy, reducing the risk of failure of drug candidates by improving data quality and boosting throughput, leading to a faster time to market

With our solutions, researchers can run more assays with less reagent, reduce the cost to bring drugs to market, improve data reliability, and minimize manual labor.

Reduced costs and timelines

BICO accelerates the drug discovery pipeline through both partial and full lab orchestration with Green Button Go. By automating scheduling, instrument coordination, and workflow execution, compounds move from idea to the market faster, reducing labor, consumables, and overall project costs.

Improved success rates

Our platform helps researchers generate more predictive preclinical models. 3D bioprinted tissues better replicate human physiology, while automated liquid handling, single-cell dispensing, and integrated workflows allow precise assay design. Together, these tools improve the accuracy of screening, hit identification, and downstream validation, increasing the likelihood of successful drug candidates.

Enhanced reproducibility and data quality

Automation removes variability caused by manual handling, ensuring consistent experimental execution and sample processing. By standardizing every step from single-cell isolation to high-throughput assays, BICO technologies deliver reproducible, high-quality data, enabling confident interpretation and robust decision-making.

Addressing complex biological targets

Modern drug discovery often targets complex, heterogeneous biological systems. BICO supports these efforts by through various approaches, including single-cell proteomics, 3D in vitro model creation, and integrated automated workflows. This allows researchers to investigate difficult targets with precision, scale experiments effectively, and capture biologically relevant insights that are difficult to achieve with traditional 2D or bulk methods.

Sub-Applications

BICO empowers a broad range of interconnected workflows, from early compound screening to precision-guided therapies in industry and research by streamlining drug discovery, from high-throughput screening to biologics development. Its technologies enable customers to accelerate time-to-results while reducing costs and improving reproducibility.

High-Throughput Screening

Rapid testing of large compound libraries against validated molecular targets enables the identification of initial hits for further development. High-throughput screening automation relies on precise compound dispensing to reduce reagent usage and improve reproducibility, making it central to modern drug discovery screening.

Personalized Medicine

The integration of biomarker analysis and patient-derived cell models into drug development models enables researchers to tailor treatments to individual patients. This approach improves therapeutic efficacy, minimizes side effects, and aligns with the shift toward precision medicine. BICO enables this with advanced 3D bioprinting, automated cell line development, and patient-specific assay platforms.

Dose Response and Compound Dilution

Systematic evaluation of compound efficacy and safety involves generating dose-response curves, determining potency (EC50/IC50), and assessing selectivity. Miniaturization and sub-nanoliter precision dispensing make it possible to achieve accurate profiling whilst reducing reagent use and costs, thereby streamlining pharmaceutical testing and drug toxicity screening workflows.

Products for Drug Discovery

Together, BICO technologies cover the full spectrum of drug discovery, from miniaturized compound screening and dose-response profiling to biologics development, assay imaging, and advanced tissue modeling, enabling a connected, efficient, and reproducible R&D pipeline.

Contact Us

Get in touch with a BICO expert today to discuss your research goals, explore our innovative solutions, and find the approach that perfectly aligns with your lab’s needs. Whether you’re looking for a quote, a product demo, or technical guidance, our team is here to support you every step of the way.
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