Label-Free Detection of Bacteria to Prevent Antibiotic Resistance

According to the World Health Organization (WHO), antibiotic resistance is now one of the greatest threats to global health, food safety and development. This immunity of bacteria is a natural evolutionary process and that is further accelerated by the misuse of antibiotic treatments. For more precise treatment of infections, in situ characterization of the infected region would be ideal, as it would allow specific treatment against the pathogens. With this in mind, researchers of the Imperial College London developed a novel fiber-optics Raman spectroscopy sensor for the label-free identification of bacteria using Nanoscribe’s microfabrication technology.

The invention of antibiotics is certainly one of the great milestones of modern medicine and has relieved many people’s fear of infectious diseases such as tuberculosis or pneumonia. However, the fight against bacterial infections is once again coming into focus of experts in medicine and biology. Due to the high use or even misuse of antibiotics, bacteria become increasingly resistant to their treatment and even minor infections can once again become life-threatening. To counteract this, antibiotics should only be administered when necessary and in accordance with the respective disease pattern.

To drive innovations in photonics and applications of medical instrumentations and optical sensing, such as the intriguing fiber optical SERS probe, Nanoscribe recently introduced its latest 3D printer Quantum X align. With its proprietary on-fiber print set and tilt correction in all spatial directions, the new 3D printer may already provide the answer to the challenges of the on-fiber printed SERS probes and paves the way for further improvements and new innovations.

The gold-coated fiber optical SERS probe. The green color of the probe is a diffraction phenomena of the microstructured surface. Image: J. A. Kim, Imperial College London

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