Bioprinting
3D bioprinting is revolutionizing tissue engineering and the future of health. BICO's Bioprinting business area provides the most cutting edge technologies, to the brightest minds, to enable this future.
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What is Bioprinting?
Why Bioprinting?
Applications of Bioprinting
Unfortunately, 21 patients per day die due to organ transplant shortages. Being able to bioprint organs could help clinicians keep up with patients or eliminate the list entirely. While this solution is far down the line, it is one of the most impactful possibilities in the field.
Bioprinting by Numbers
Customer Spotlights
There is currently no way to repair damaged heart muscles from heart attacks, so many patients around the world wait on long heart transplant lists. Even for the lucky few who find a matching donor, there are more hurdles (i.e., organ viability, geographical distance, immune rejection). Therefore, heart disease remains the leading cause of death worldwide. According to the World Health Organization, 17.9 million lives are lost each year to cardiovascular diseases.
Dr. Carmine Gentile, leader of the Cardiovascular Regeneration Group at the University of Technology Sydney (UTS), announced in 2020 that his lab had “developed a technology that can 3D model and bioprint personalized hearts for transplantation, using the patient’s own stem cells so that there’s no risk of rejection.” Specifically, the technology identified the optimal conditions for cells to create blood vessels within bioprinted heart patches.
There is currently no way to repair damaged heart muscles from heart attacks, so many patients around the world wait on long heart transplant lists. Even for the lucky few who find a matching donor, there are more hurdles (i.e., organ viability, geographical distance, immune rejection). Therefore, heart disease remains the leading cause of death worldwide. According to the World Health Organization, 17.9 million lives are lost each year to cardiovascular diseases.
Dr. Carmine Gentile, leader of the Cardiovascular Regeneration Group at the University of Technology Sydney (UTS), announced in 2020 that his lab had “developed a technology that can 3D model and bioprint personalized hearts for transplantation, using the patient’s own stem cells so that there’s no risk of rejection.” Specifically, the technology identified the optimal conditions for cells to create blood vessels within bioprinted heart patches.
“We are using the patient’s own stem cells so that there’s no risk of rejection.”
Dr. Carmine Gentile
To address the need for personalized oncology drug testing, CEO Ishani Malhotra founded Carcinotech, the Edinburgh-based biotech that is bioprinting patient-specific testing models with cells from biopsy samples. Find out how these ingenious researchers benefited from expert support from CELLINK, a BICO company.
Why is Breast Cancer Awareness month important to you?
The annual breast cancer awareness campaign helps women and men (who also suffer from breast cancer) understand the importance of self-checking and scheduling lab tests to catch the disease early. Breast Cancer Awareness Month is also a chance to highlight the amazing progress researchers are making to develop more treatments options for breast cancer.
Why is Breast Cancer Awareness month important to you?
The annual breast cancer awareness campaign helps women and men (who also suffer from breast cancer) understand the importance of self-checking and scheduling lab tests to catch the disease early. Breast Cancer Awareness Month is also a chance to highlight the amazing progress researchers are making to develop more treatments options for breast cancer.
Breast cancer construct
“Carcinotech’s testing model also makes it possible to screen thousands of potential cancer drug compounds in a high-throughput manner, with disease models that more accurately replicate human tissue and minimize the use of animals for preclinical testing”
Ishani Malhotra, CEO Carcinotech
personalized medicine
Ronawk T-blocks are disrupting the industry by enabling the production of adult stem cells in large quantities.
The study of adult stem cells has increased exponentially because of recent technological innovations in the life sciences, especially within the field of bioprinting. The array of applications under consideration runs the gamut—from reversing baldness to managing diabetes to transplanting personalized bioprinted organoids.
With the latter, researchers are envisioning culturing a patient’s own adult stem cells to create viable organoids that could be transplanted into the patient with no need for the long-term immunosuppressant drugs they would have taken with a donated organ.
The study of adult stem cells has increased exponentially because of recent technological innovations in the life sciences, especially within the field of bioprinting. The array of applications under consideration runs the gamut—from reversing baldness to managing diabetes to transplanting personalized bioprinted organoids.
With the latter, researchers are envisioning culturing a patient’s own adult stem cells to create viable organoids that could be transplanted into the patient with no need for the long-term immunosuppressant drugs they would have taken with a donated organ.
“The tissue block, or T-block, is a 3D scaffold that is expandable and modular to grow stem cells. The goal is to efficiently expand a patient’s own stem cells to engineer organoids or grafts that could be used in life-saving surgeries.”
A.J. Mellott, PhD
Karande and his team have developed a bioink made up of human endothelial cells, human pericyte cells and animal collagen. They used the CELLINK BIO X and Temperature Controlled Printhead to ensure that these constructs could be printed.
This combination of key elements enabled the cells to start communicating and more importantly begin forming a biologically relevant vascular structure within the span of a few weeks. Once blood vessels formed, nutrients and waste could be exchanged to keep the graft alive. The groups significant development highlights the vast potential of 3D bioprinting in precision medicine, where solutions can be tailored to specific situations.
Karande and his team have developed a bioink made up of human endothelial cells, human pericyte cells and animal collagen. They used the CELLINK BIO X and Temperature Controlled Printhead to ensure that these constructs could be printed.
This combination of key elements enabled the cells to start communicating and more importantly begin forming a biologically relevant vascular structure within the span of a few weeks. Once blood vessels formed, nutrients and waste could be exchanged to keep the graft alive. The groups significant development highlights the vast potential of 3D bioprinting in precision medicine, where solutions can be tailored to specific situations.
“…we could potentially even think of using this as a therapy for burn victims.”
Pankaj Karande
Associate Professor
Good Clean Love is advocating for the use of a 3D model of human tissue developed by MatTek as a more relevant alternative to testing women’s personal care products on animals.
Although available over the counter (OTC) in US drugstores, personal lubricants are classified as medical devices by the Food and Drug Administration (FDA). As such, these intimate products are subject to regulatory requirements that include animal-based skin sensitization toxicity testing, like in vivo rabbit vaginal irritation (RVI) and in vivo guinea pig maximization tests (Costin, 2020). But some argue that, beyond the ethical concerns, testing solely on animals is both outdated and detrimental to the health of female users because of the significant physiological differences.
Although available over the counter (OTC) in US drugstores, personal lubricants are classified as medical devices by the Food and Drug Administration (FDA). As such, these intimate products are subject to regulatory requirements that include animal-based skin sensitization toxicity testing, like in vivo rabbit vaginal irritation (RVI) and in vivo guinea pig maximization tests (Costin, 2020). But some argue that, beyond the ethical concerns, testing solely on animals is both outdated and detrimental to the health of female users because of the significant physiological differences.
“There are currently so many problems with women’s healthcare products. Partly, because they depend on archaic animal testing to approve new products. A lot of research shows that animal testing results do not provide an accurate reflection of safety.”
Wendy Strgar, CEO at Good Clean Love
Publications
Featured Product Offering
BIO X6™
With six printheads in total for unparalleled versatility, the BIO X6 bioprinter from CELLINK makes it easier to produce more complex and sophisticated constructs with a broader range of materials, cells and crosslinking tools. With many possible combinations, the six slots significantly increase throughput, cut down on print time and improve experiment efficiency. The BIO X6 is the preferred system for researchers seeking to enhance 3D cell culturing, tissue engineering, disease modeling and drug screening applications.
EpiDerm™
MatTek’s patented EpiDerm system is a leading in vitro testing technology for dermal toxicologists and formulation scientists. With multiple ECVAM validations and OECD accepted test guidelines, EpiDerm is a proven in vitro model system for chemical, pharmaceutical and skin care product testing.
LifeInk 220
Quantum X bio
Further Reading
3D Bioprinting Set To Propel Medical Research Forward
3D printing techniques are being used in medical research to establish more personalized treatment approaches and accelerate drug discovery. The technology is unlocking the potential of 3D cell culture approaches to better replicate the human body, gain a greater understanding of various cell types and, ultimately, develop patient- and organ-specific treatment pathways.
How 3D Bioprinters Are Advancing Cancer Research
Although the past decade has yielded significant reductions in the cancer death rate around the world, cancer is still the second leading cause of death globally, accounting for about 10 million deaths in 2020. This sobering statistic makes the search for more efficient cancer solutions an important priority for researchers the world over. While animal models have advanced our understanding of the molecular mechanisms associated with cancer and its progression, therapeutics developed with these interspecies models often fail in clinical trials because the efficacy results do not translate to humans.
Fighting to End Animal Testing
Drug and cosmetic developers are still mandated to test on animals, even if it doesn’t benefit the science. This leads to the experimentation on and death of hundreds of millions of primates, dogs, rabbits, mice and other animals. With 3D bioprinting, BICO is replacing outdated methods for drug discovery to end animal testing once and for all.
First pig-to-human heart transplant
In recent achievements, an important step to alleviate the organ donor shortage has been achieved with the first pig-to-human heart transplant. Solving the organ donor shortage is one of CELLINK’s goals with 3D bioprinting, and we look forward to how our technology will contribute to solving the shortage through 3D bioprinted organs.
